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KMID : 0361120160300020094
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Korean Journal of Transplantation
2016 Volume.30 No. 2 p.94 ~ p.97
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Tacrolimus-induced, Transplant-associated Thrombotic Microangiopathies after Lung Transplantation
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Choi Ji-Soo
Kim Song-Yee
Lee Jin-Gu
Kim Soo-Jeong
Song Myung-Jin
Yoon Bo-Ra
Kim Moo-Hyun
Park Moo-Suk
Paik Hyo-Chae
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Abstract
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We report a case of tacrolimus-induced transplant-associated thrombotic microangiopathies (TA-TMA) after lung transplantation. A 71-year-old man underwent lung transplantation secondary to idiopathic pulmonary fibrosis. After 4 months, he presented with abdominal discomfort and dyspnea, and was diagnosed with hemolytic anemia and thrombocytopenia. Tacrolimus was considered the cause of the TMA. Tacrolimus was stopped and several sessions of plasma exchange were performed immediately after diagnosis of TA-TMA. However, his platelet count did not normalize, gastrointestinal bleeding was recurrent, and severe pneumonia developed, following which he died. TA-TMA are rare but severe, life-threatening complications in lung transplant recipients. Therefore, the possibility of TA-TMA should be considered in posttransplant recipients.
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KEYWORD
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Thrombotic microangiopathies, Lung transplantation, Tacrolimus
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